Argonaute 2 Is the Catalytic Engine of Mammalian
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چکیده
http://www.sciencemag.org/cgi/content/full/305/5689/1437 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/1102513/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/cgi/content/full/305/5689/1437#related-content http://www.sciencemag.org/cgi/content/full/305/5689/1437#otherarticles , 15 of which can be accessed for free: cites 42 articles This article 515 article(s) on the ISI Web of Science. cited by This article has been http://www.sciencemag.org/cgi/content/full/305/5689/1437#otherarticles 85 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/molec_biol Molecular Biology : subject collections This article appears in the following
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Argonaute2 is the catalytic engine of mammalian RNAi.
Gene silencing through RNA interference (RNAi) is carried out by RISC, the RNA-induced silencing complex. RISC contains two signature components, small interfering RNAs (siRNAs) and Argonaute family proteins. Here, we show that the multiple Argonaute proteins present in mammals are both biologically and biochemically distinct, with a single mammalian family member, Argonaute2, being responsible...
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